有没有弥漫大B淋巴瘤TP53突变治愈了的病友呢？

心情似水

范莫离 发表于 2022-04-17 18:53
https://onlinelibrary.wiley.com/doi/full/10.1002/ijc.30838

TP53 mutation and survival in aggressive B cell lymphoma
Abstract
TP53 is mutated in 20–25% of aggressive B-cell lymphoma (B-NHL). To date, no studies have addressed the impact of TP53 mutations in prospective clinical trial cohorts. To evaluate the impact of TP53 mutation to current risk models in aggressive B-NHL, we investigated TP53 gene mutations within the RICOVER-60 trial. Of 1,222 elderly patients (aged 61–80 years) enrolled in the study and randomized to six or eight cycles of CHOP-14 with or without Rituximab (NCT00052936), 265 patients were analyzed for TP53 mutations. TP53 mutations were demonstrated in 63 of 265 patients (23.8%). TP53 mutation was associated with higher LDH (65% vs. 37%; p < 0.001), higher international prognostic index-Scores (IPI 4/5 27% vs. 12%; p = 0.025) and B-symptoms (41% vs. 24%; p = 0.011). Patients with TP53 mutation were less likely to obtain a complete remission CR/CRu (CR unconfirmed) 61.9% (mut) vs. 79.7% (wt) (p = 0.007). TP53 mutations were associated with decreased event-free (EFS), progression-free (PFS) and overall survival (OS) (median observation time of 40.2 months): the 3 year EFS, PFS and OS were 42% (vs. 60%; p = 0.012), 42% (vs. 67.5%; p < 0.001) and 50% (vs. 76%; p < 0.001) for the TP53 mutation group. In a Cox proportional hazard analysis adjusting for IPI-factors and treatment arms, TP53 mutation was shown to be an independent predictor of EFS (HR 1.5), PFS (HR 2.0) and OS (HR 2.3; p < 0.001). TP53 mutations are independent predictors of survival in untreated patients with aggressive CD20+ lymphoma. TP53 mutations should be considered for risk models in DLBCL and strategies to improve outcome for patients with mutant TP53 must be developed.

看来还是有百分之四十多的突变者会好。

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ALK阴性大细胞瘤

一一宝贝的宝贝 发表于 2022-04-17 17:18
我们也p53突变

我也是P53突变

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心情似水

zhangwenjing 发表于 2022-4-19 04:03
我还是双表达，Tp53突变，p53蛋白缺失80+%，LDH乳酸脱清酶发病时高达一千多，Ki6790+%，可以说该有的预后不 ...

什么方案呢？看您的经历就觉得自己也会好运。

心情似水

zhangwenjing 发表于 2022-4-19 04:03
我还是双表达，Tp53突变，p53蛋白缺失80+%，LDH乳酸脱清酶发病时高达一千多，Ki6790+%，可以说该有的预后不 ...

光明顶

zhangwenjing 发表于 2022-04-19 04:03
我还是双表达，Tp53突变，p53蛋白缺失80+%，LDH乳酸脱清酶发病时高达一千多，Ki6790+%，可以说该有的预后不好因素我全占了。但是二疗就cr了，六了后经过采干，自己移植经过一年休息，现在越来越好了！病友们加油！只要规范治疗，化疗敏感，天空漂来一个字那都不是事。

兄弟用的什么方案，我情况跟你差不多

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zhangwenjing

光明顶 发表于 2023-07-14 06:49
兄弟用的什么方案，我情况跟你差不多

r_chop加维纳托克加自体移植

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