已经使用R-CHOP方案开始化疗，可以调整用Pola吗？

cgf

已经使用R-CHOP方案开始化疗，一疗已完成，可以调整用Pola吗？

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小猪泡泡

上pola一般就是rchp，减去一个长春新碱，但是要考虑到底目前情况需要不需要换，是不是处于高危？或者等中期疗效评估后再做决定

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cgf

健康是福CR 发表于 2023-02-26 18:28
为什么呢，我也是Rchop

看网上介绍，Pola对弥漫大b效果比R-CHOP好，也已经写进了2022诊疗方案中，可能是现在药不好买，所以是II级推荐

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橙色雨丝

"In our trial, point estimates that suggested a benefit with pola-R-CHP among the various patient subgroups evaluated were observed in patients older than 60 years of age, in patients who had an IPI score between 3 and 5, and in patients with the activated B-cell–like subtype of DLBCL. Conversely, subgroups that did not show a clear benefit were patients 60 years of age or younger, those who had lower IPI scores, those who had bulky disease, and those who had the germinal-center B-cell–like subtype of DLBCL."

如果年龄大于60岁，IPI评分高于3分，ABC亚型，可以考虑Pola-R-CHP，如果年龄小于60岁，IPI评分低，有大肿块，GCB亚型，那么获益不明显，没有必要。

怕啥

我也有一样的疑问，如果是飞生发中心型，说是rchop方案一般，但现在找不到权威医生，感觉要去一线城市比较前沿的医院

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健康是福CR

为什么呢，我也是Rchop

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健康是福CR

R~chop大B标准方案

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菜泱泱

经济能承受的话

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wonderfuy

同问

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cgf

橙色雨丝 发表于 2023-02-27 13:31
"In our trial, point estimates that suggested a benefit with pola-R-CHP among the various patient subgroups evaluated were observed in patients older than 60 years of age, in patients who had an IPI score between 3 and 5, and in patients with the activated B-cell–like subtype of DLBCL. Conversely, subgroups that did not show a clear benefit were patients 60 years of age or younger, those who had lower IPI scores, those who had bulky disease, and those who had the germinal-center B-cell–like subtype of DLBCL."

如果年龄大于60岁，IPI评分高于3分，ABC亚型，可以考虑Pola-R-CHP，如果年龄小于60岁，IPI评分低，有大肿块，GCB亚型，那么获益不明显，没有必要。

谢谢雨丝！家属61岁，IPI 4分，非生发中心。R-CHOP已经一疗，如果调整，需要评效后调吗？能否从2疗就开始调？

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橙色雨丝

cgf 发表于 2023-02-27 20:39
谢谢雨丝！家属61岁，IPI 4分，非生发中心。R-CHOP已经一疗，如果调整，需要评效后调吗？能否从2疗就开始调？

如果可以买到，可以随时改用新方案。

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liuyj

橙色雨丝 发表于 2023-02-27 13:31
"In our trial, point estimates that suggested a benefit with pola-R-CHP among the various patient subgroups evaluated were observed in patients older than 60 years of age, in patients who had an IPI score between 3 and 5, and in patients with the activated B-cell–like subtype of DLBCL. Conversely, subgroups that did not show a clear benefit were patients 60 years of age or younger, those who had lower IPI scores, those who had bulky disease, and those who had the germinal-center B-cell–like subtype of DLBCL."

如果年龄大于60岁，IPI评分高于3分，ABC亚型，可以考虑Pola-R-CHP，如果年龄小于60岁，IPI评分低，有大肿块，GCB亚型，那么获益不明显，没有必要。

纵隔弥漫大B，非生发，大肿块9*7.8*7，伴中心坏死。看您说大肿块pola获益不大，这个情况适合用吗？刚做完一疗标准rchop

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橙色雨丝

liuyj 发表于 2023-3-2 06:44
纵隔弥漫大B，非生发，大肿块9*7.8*7，伴中心坏死。看您说大肿块pola获益不大，这个情况适合用吗？刚做完 ...

POLARIX研究中未纳入原发纵隔大B，所以严格的说不属于POLA的适应症。

做了个梦

橙色雨丝 发表于 2023-03-02 08:36
POLARIX研究中未纳入原发纵隔大B，所以严格的说不属于POLA的适应症。

雨丝大神想问下滤泡3B，R-CHOP五次化疗后有SUV值有显著降低但评分只有4；医生建议自体移植或换（Pola+)RGDP，您觉得哪种好一些，感谢

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橙色雨丝

做了个梦 发表于 2023-3-8 12:57
雨丝大神想问下滤泡3B，R-CHOP五次化疗后有SUV值有显著降低但评分只有4；医生建议自体移植或换（Pola+)RG ...

没有见到过Pola-R-GDP的临床试验数据，不好评价。

shengying

cgf 发表于 2023-02-26 18:33
看网上介绍，Pola对弥漫大b效果比R-CHOP好，也已经写进了2022诊疗方案中，可能是现在药不好买，所以是II级推荐

我妈妈是弥漫大B 非生发中心双表达 打算第三个疗加pola

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加油吧pan

cgf 发表于 2023-02-27 20:39
谢谢雨丝！家属61岁，IPI 4分，非生发中心。R-CHOP已经一疗，如果调整，需要评效后调吗？能否从2疗就开始调？

我们在东肿，医生说不考虑经济因素的话，一线用pola肯定会好一些，一线目的是治愈，有更好的肯定用更好的。我们也是一疗用rchop，二疗要改pola-rchp。好像就是pola替换掉长春新碱

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